Module III represents CAFs expressing COL1A1, COL1A2, and COL3A1 [35] enriched in the cancer regions, whereas module IV identifies a subset known as myofibroblasts (myCAFs) (COL12A1, THBS2) that mainly contribute to extracellular matrix remodeling and growth and metastasis of cancer cells [85, 86]. The gene discussed is COL3A1; the disease is cancer.