As shown in Fig. 11B, this nanomedicine CS-1@PB[HM] NPs not only exhibits deep penetration in tumor tissues, but also releases CS-1 in a photothermally controlled manner, inducing strong pyrolysis and GSDME-dependent tumor cell pyrolysis, promoting the release of tumor antigens and DAMPs, and finally inducing DCs maturation, which effectively stimulates the adaptive anti-tumor efficacy and improves the anti-PD-L1 efficacy. Here, CD274 is linked to neoplasm.