Reportedly, Mn2+ can improve the sensitivity of the DNA sensor cGAS and its downstream adaptor protein STING [129] and act as a cGAS-STING agonist, directly inducing IFN-I and cytokine production in the absence of any infection, resulting in activation of innate immune response, and enhancing anti-tumor immunotherapy [130, 131]. The gene discussed is CGAS; the disease is neoplasm.