Then, STING polymers recruit and activate TANK-binding kinase 1 (TBK1) which phosphorylates STING and interferon regulatory factor 3 (IRF3) and induces the production of IFN-Is and many other proinflammatory cytokines, regulating the natural anti-tumor-immune-responses in vivo [126–128]. Here, IRF3 is linked to neoplasm.