As a macrophage transducer and oxygen generator, LMWHA-MPB can reshape TAMs phenotype (pro-tumor M2 → anti-tumor M1) in tumor hypoxic areas and continuous supply of H2O2 by LMWHA to generate sufficient O2 to relieve hypoxia through CAT-like catalytic activity of MPBNPs, and facilitate O2 self-supplied sonodynamic therapy (SDT). This evidence concerns the gene CAT and neoplasm.