APP and Alzheimer disease: In contrast, ABX treatment of APP/PS1-21 mice did not significantly alter the number of plaque-associated microglia in 7-month-old, 3-month-old females or males [37], whereas GF 5xFAD mice showed an increase in hippocampal microglia density and plaque-associated microglia [109], indicating overall partially divergent microglial phenotypes across different AD mouse models.