PTEN and cancer: To explore the mechanism of NONO-mediated AS regulation of PTEN, we used the normalized pan-cancer dataset (TCGA, PANCAN, N = 10535, G = 60499) from the UCSC database (https://xenabrowser.net/) and found broad correlation (Pearson) between the transcription of NONO and 41 RNA modification genes (10 m1A-related genes, 10 m5C-related genes, 21 m6A-related genes) in 37 cancer types (Fig. S5A).