Contrarily, most PPARα target genes were upregulated in CLL with the exception of CPT1B, involved in FA transport in the mitochondria (Fig. 2E), while expression of PPARA itself was significantly lower in CLL T cells (Fig. 2F). Expression of the transcription factors PPRG (PPARγ) and NR1H3 (LXR) was not significantly different between both groups (Fig. 2F), however, most LXR target genes were downregulated in CLL T cells, and PPARγ target genes showed a mixed response (Fig. 2E). Here, PPARA is linked to B-cell chronic lymphocytic leukemia.