Upon activation, expression of these proteins increased significantly in HD T cells but not in CLL T cells (Fig. 3E, Supplementary Fig. 3E), including CD25high cells (Fig. 3F, Supplementary Fig. 3F), where a statistically significant reduction of protein levels was observed in the CD8+ compartment compared to healthy CD8+ cells (Supplementary Fig. 3F). This evidence concerns the gene CD8A and Huntington disease.