Accordingly, multiple target genes of SREBP1/2 were downregulated in CLL T cells upon stimulation, including Stearoyl-CoA Desaturase (SCD), an SREBP1 target involved in FA desaturation, LDLR, an SREBP2 target we previously found decreased at the protein level (Fig. 1E, Supplementary Fig. 1G), and mevalonate diphosphate decarboxylase (MVD), an SREBP2 target involved in cholesterol synthesis (Fig. 2D, E). The gene discussed is SREBF1; the disease is B-cell chronic lymphocytic leukemia.