Certain clinicopathologic variables encompass younger age, greater lesion size, hormone receptor-negative, Human Epidermal growth factor Receptor 2 (HER2) positivity, high nuclear grade (HNG), comedo necrosis, and positive margin status are linked to death or recurrence in DCIS patients7,8, the significance and connection between these characteristics are not well understood, which complicates the precise prediction of which DCIS patients are most likely to develop invasive cancer. Here, NR4A1 is linked to ductal breast carcinoma in situ.