PI16 and colorectal carcinoma: Among these, ADAMDEC1+ fibroblasts are characterized by expressing secreted factors such as CCL2/11/13, CXCl14, while PI16+ fibroblasts, on the other hand, can be viewed as fibroblasts associated with ECM deposition and remodeling, expressing not only COL14A1 but also PROs like DCN, LUM, PRELP, OGN. The distinctive features of these tissue-resident fibroblasts can be linked to their molecular phenotype of CRC tissue.