ANXA5 and neoplasm: Regarding the six discerned genes in the model, ANXA5 can promote GC by affecting ECM-related processes and immune infiltration55 with studies suggesting that ANXA5 is not only closely associated with tumorigenesis and progression through PI3K/Akt/NF-κB pathway, but also enhances immunogenicity of tumor cells and the efficacy of related chemotherapy drugs56–58.