PRKCD and gastric cancer: In proteasome, colorectal neoplasia differentially expressed can promote the degradation of serine and arginine-rich splicing factor 6, which plays a role in regulating the sensitivity of GC to drugs44,45, and the tripartite motif 69 can inhibit the anoikis resistance and metastasis of GC by mediating the degradation of protein kinase C delta through the ubiquitin-proteasome pathway46.