Conversely, enhancer-driven C-C motif chemokine ligand 2 (CCL2) production in pancreatic ductal adenocarcinoma leads to the recruitment of TNF-α-positive macrophages and triggers the transition from a “classical” subtype to a more aggressive “basal-like” subtype [288]. This evidence concerns the gene CCL2 and pancreatic ductal adenocarcinoma.