The CRC formed by E74 like ETS transcription factor 3 (ELF3), KLF5, and GATA6 upregulates peroxisome proliferator-activated receptor gamma (PPARG) in esophageal cancer, leading to increased synthesis of fatty acids, phospholipids, and sphingolipids [221]. The gene discussed is KLF5; the disease is colorectal carcinoma.