It plays a significant role in controlling tumor cell glycolysis through the transcriptional regulation of various metabolic enzymes within the glycolytic pathway, including glucose transporters 1 and 3 (GLUT1/3), pyruvate dehydrogenase kinase 1 (PDK-1), lactate dehydrogenase A (LDH-A), and pyruvate kinase M2 (PKM-2). The gene discussed is LDHA; the disease is neoplasm.