By increasing the expression of SRPKs (CLK1 and SRPK1), changing the intracellular localization of SFs and their capacity to bind to other proteins and pre-mRNA, hypoxia may affect the hyperphosphorylation and expression of SFs (SRSF1, SRSF2, SRSF3, SRSF6, SAM68, HuR, hnRNPA1, hnRNPM, PRPF40B, and RBM4) to adapt to the hypoxic environment and the trend of tumor growth [78–84]. This evidence concerns the gene RBM4 and neoplasm.