Colon cancer has also been found to activate the similar mechanism for Sam68, which binds phosphorylated Sam68 to the 3’ untranslated region (3’UTR) of the SRSF1 transcript and facilitates intron inclusion, which is necessary for the synthesis of full-length SRSF1 transcripts [23]. Here, SRSF1 is linked to malignant colon neoplasm.