A cancer interferon gamma response was frequently associated with receipt of strong IL-15 signals (28% of tumor subclones) or related cytokine receptors such as: Toll-like receptor 2 (TLR2: 19% subclones), Interleukin-22 Receptor Subunit Alpha 1 (IL22RA1: 17% subclones), Interleukin-12 Receptor Subunit Beta-1 (IL12RB1: 15% subclones) (Figure S16). The gene discussed is IL18R1; the disease is neoplasm.