Interestingly, the upregulation of ZIPK in the cortex of AD patients is associated with the dysregulation of apoptosis-related proteins such as the Bcl-2 protein family members and prostate apoptosis response-4 (Par-4) [10, 53], all of which are important factors in the neuronal apoptosis cascade. The gene discussed is DAPK3; the disease is Alzheimer disease.