For CKD and CAD, none of the proteins we identified in our forward MR were associated in the reverse MR, though this was the case for 7 of the 21 BMI-associated proteins (CXCL16, LGALS3, GALNT10, PSCA, IL12RB2, ITGAL, SERPINA7). Here, IL12RB2 is linked to chronic kidney disease.