After adding trans instruments in our MR models, we found 4 more proteins with significant causal evidence for T2D (LGALS4, MENT, PDIA5, and PPM1B, FDR-adjusted p-value < 0.05), with LGAL34 significant after Bonferroni correction (p-value < 8.7 × 10−6). Here, PDIA5 is linked to type 2 diabetes mellitus.