Six proteins had significant causal evidence with regards to T2D (median p-value across the four MR methods <0.05, FDR-adjusted) without evidence of pleiotropy (MR-Egger intercept p-value > 0.05): MANSC4, GLRX5, NUCB2, PAM, ARG1, and NCR3LG1, (see Fig. 3A and Supplementary Data 9), with PAM and MANSC4 significant after a more stringent Bonferroni correction (p-value < 9.2 × 10−6). This evidence concerns the gene GLRX5 and type 2 diabetes mellitus.