Mechanistically, PARP1 promote the NF-κB expression, which could regulate downstream inflammatory cytokines, including IL-6, IL-10, IL-12p70, CCL2, IFN-γ in M1 macrophages, leading to the accumulation of proinflammation factors and ultimately exacerbating prostatitis. The gene discussed is NFKB1; the disease is male reproductive organ cancer.