In the present study, we witnessed a remarkable recruitment-enhancing effect of PARP1 on both macrophages and neutrophils in the prostatitis model, and significantly higher expression levels of pro-inflammatory cytokines IL-6, IL-12p70p70, CCL2, and TNF, while the expression of the anti-inflammatory cytokine IL-10 was notably lower. Here, PARP1 is linked to male reproductive organ cancer.