Regulates ITGB2 gene transcription by binding to hypoxia inducible factor‐1 (HIF‐1α). The lncRNA AC078850.1/HIF‐1α complex promotes NOD‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome‐mediated pyroptosis and foam cell formation through a ROS‐dependent pathway in atherosclerosis. Here, NLRP3 is linked to atherosclerosis.