TNF and schizophrenia: Even though we make the argument of DA and midbrain due to its understudied nature and putative relevance because of currently approved treatments, we have to recognize other regional markers that have been implicated in schizophrenia, such as serotonin hyperactivity(Mahdiar et al., 2023) and alterations in neuroinflammatory signaling via increases in IL6 and TNFα (Purves-Tyson et al., 2019) that may be important players in the distributed alterations among several brain regions reported in this article.