EIF2AK4 and neoplasm: Moreover, GSEA of RNA-seq data from tumour sample mRNA showed a transcriptome response to prolonged in vivo GCN2 inhibition or depletion that was highly concordant with our findings in cultured cells after short-term pharmacological inhibition, including the induction of “MYC targets” and the repression of “glycolysis” (Fig 1E and F).