Monoallelic MYBPC3 LoF variants are the most common genetic cause of autosomal dominant hypertrophic cardiomyopathy, and biallelic truncating variants cause severe neonatal cardiomyopathy, while monoallelic missense variants are associated with dilated and hypertrophic cardiomyopathy (57, 58) (OMIM# 615396 and 115197). Here, MYBPC3 is linked to hypertrophic cardiomyopathy.