In addition to genes with RG burdens that surpass thresholds for genome-wide significance, several additional genes not previously implicated in CHD approached this value and had false discovery rate values < 0.05 (VPREB3, CD36, USP17L7) or < 0.1 (OR5H2, and TNS1) (Fig. 1B) suggesting that some may prove to be bona fide CHD genes. The gene discussed is TNS1; the disease is coronary artery disorder.