Importantly, in addition to cilia-associated genes, we identified recessive variants in four genes previously implicated in cardiomyopathy (MYH6, UNC45B, MYO18B, and MYBPC3) that are expressed in embryonic cardiomyocytes; RGs in these genes contributed to left-sided CHD phenotypes. The gene discussed is UNC45B; the disease is cardiomyopathy.