GPT and cryptosporidiosis: After 21 dPI, liver enzyme levels were significantly (P < 0.001) lower in mice treated with Nitazoxanide or L. spinosa extracts, and the best effect was observed in the LS-BuOH extract (200 mg/Kg) treated group where ALT, AST, and ALP were restored towards control healthy levels indicating the strong anti-cryptosporidial effect of LS-BuOH extract against cryptosporidiosis.