The systemic inflammatory response observed in acute COVID-19, characterized by elevated levels of cytokines, such as IL-2, IL-10, IL-6, IL-8, C-Reactive Protein (CRP), and Tumor Necrosis Factor (TNF)-alpha, triggers acute phase reactions and, if sustained, may lead to end-organ damage [74,75]. Here, CXCL8 is linked to COVID-19.