RNASE2 and filariasis: Eosinophils produce crystalloid granules that contain major basic protein (MBP), eosinophilic cationic protein (ECP), eosinophil-derived neurotoxin (EDN) and eosinophil peroxidase (EPO), which are associated with the killing of the filarial progeny (microfilariae (MF)) and drug-induced adverse events in filariasis patients.