On the other hand, earlier reports also showed that TLR3 signaling directly or indirectly induces apoptosis in gastric cancer [35], colon cancer [36], breast cancer [37, 38], prostate cancer [39], ovarian cancer [40], hepatocellular carcinoma [41, 42] and head and neck cancer cells [43–45]. Here, TLR3 is linked to hepatocellular carcinoma.