Knocking down TICAM-1 also significantly suppressed 10 μg/mL poly(I:C)-induced CXCL10 secretion in the two ESCC lines, suggesting the TLR3/TICAM-1 pathway plays a key role in mediating CXCL10 secretion (Fig. 4). This evidence concerns the gene TICAM1 and esophageal squamous cell carcinoma.