CD8A and non-small cell lung carcinoma: Recently, the cellular composition of TLS was characterized in detail using immunohistochemical markers on NSCLC tissue, and have been found to consist of B-cells (CD20 + or CD19+), follicular dendritic cells (CD21+, CD35+, and CD23+), plasma cells (CD138 + and CD269+), T-cells (CD3+,CD8+, or CD4 + subpopulations), T-helper 1 cells (intracellular T-bet+), regulatory T-cells (FOXP3+), dendritic cells (DC-LAMP+, CD83+, or CD86+), and macrophages (CD68+).