In addition, the cytokine profile of the hypervirulent isolates in A/J mice had a profound IFNγ and IL-17 response, and lung resident CD4 T-cells isolated from A/J mice expressed significantly increased Th1 (CXCR3, Tbet) and Th17 (RORγT) markers compared with KN99α infection. This evidence concerns the gene TBX21 and infection.