IGHE and Alzheimer disease: In particular, children treated with Limosilactobacillus fermentum for 8 weeks exhibited clinical improvement in atopic symptoms, whereas children orally supplemented with Limosilactobacillus rhamnosus showed improved total serum IgE levels and AD scores.105,106 Adults with an increased Limosilactobacillus composition in the gut also exhibited reduced stress-induced depression-like behavior and fewer stress-induced changes in serotonin metabolism.107 These changes were also observed in the gut metabolome composition.