We observed a significant mutual exclusive association between TP53 driver mutation and the presence of HPV within cervix, anus, penis and head and neck, a phenomenon previously described in cervix and head and neck cancers in the PCAWG dataset [5] and mechanistically caused by HPV binding to TP53, leading to ubiquitin-mediated degradation of the protein [5,[31], [32], [33]] (Fig. S4E). Here, TP53 is linked to head and neck cancer.