Chemical carcinogenesis - receptor activation (P = 2.8024E-08; linked with 12 genes), Proteoglycans in cancer (P = 1.61597E-07; linked with 11 genes), Endocrine resistance (P = 4.31464E-07; linked with 8 genes), AGE-RAGE signaling pathway in diabetic complications (P = 5.03691E-07; linked with 8 genes), Insulin resistance (P = 9.05653E-07; linked with 8 genes), Steroid hormone biosynthesis (P = 4.6103E-06; linked with 6 genes), Prolactin signaling pathway (P = 1.02188E-05; linked with 6 genes) Fig. 3B & Supp Table 4.4. The gene discussed is PRL; the disease is Insulin resistance.