The upregulation of biomarkers such as Ki67 (antigen Kiel 67) and downregulation of BRIP1 (BRCA1-interacting protein 1), E-cadherin, and cleaved caspase-3 in diabetic patients were suggestive of acceleration of oral cancer progression in conditions of hyperglycemia [15]. This evidence concerns the gene BRIP1 and lip and oral cavity carcinoma.