In the present study, no significant association was seen between age, sex, median platelet count, mean hemoglobin concentration and AML FAB classification with the methylation status of the NR4A1 and NR4A3. However, the median WBC count was significantly higher in AML patients with methylated than those with un-methylated NR4A1. Such an association imply the importance of methylated NR4A1 in determining disease severity [26]. This evidence concerns the gene NR4A1 and acute myeloid leukemia.