39 Even when treating these small tumors in mice, examplesof small molecule drugs that induce complete or near-complete tumorregressions are rare and require multiple doses.40,41 Some immunotherapies like chimeric antigen receptor T cells (CAR-T)have efficacy following a single infusion of CAR-positive T cells(KYMRIAH, YESCARTA, ABECMA); of course these complex therapies havehigh associated costs and have yet to show strong efficacy in ERα+breast cancer.42 This evidence concerns the gene ESR1 and breast cancer.