TRPM4 expression is upregulatedin breast cancer and is associated with an estrogen response,46,47 increased migration of cancer cells,48,49 and a-UPRproteins are strongly overexpressed in ERα-positive breast cancers.50 Given the overexpression of TRPM4 in other cancers49,51 such as colorectal52 and prostate,53 investigation of ErSO-TFPy in theseand other cancers is warranted. This evidence concerns the gene ESR1 and cancer.