By analyzing transcription factors and signal transducers among the DEGs, we found that during 1W post-primary infection, transcripts involved in T cell activation [ZC3H12A (22), NFKBIA (23) and BCL3 (24)] and downstream TCR signal transduction [FOSB (25), MYC (26), and GADD45B (27)] were downregulated, suggesting an impeded T cell response upon antigen-engagement (Figure 3F). The gene discussed is ZC3H12A; the disease is infection.