NLRP3 and Alzheimer disease: However, this process seems to trigger an inflammatory response, which specifically seems to say that the binding of CD36 to Aβ activates the inflammasome NOD-like receptor family pyrin structural domain-containing 3 (NLRP3), which promotes the release of proinflammatory cytokines, chemokines, and ROS, exacerbates neuroinflammation, and leads to a progressive worsening of AD (16).