SLC2A1 and neoplasm: Targeting glucose transporter protein 1 (GLUT1) has a promotive effect on the differentiation of CD8+ T cells into effector cells, and suppression of GLUT1 not only affects tumor metabolism but also induces the accumulation of reactive oxygen species (ROS), which mediates tumor cell apoptosis through activation of the TNF-α signaling pathway (75, 76).