Furthermore, PD-L1 transfers apoptosis mediated by TNF into pyroptosis in breast cancer cells and the main mechanism is that the p-STAT3 promotes nuclear translocation of PD-L1 as well as transcription of gasdermin-C(GSDMC) and then under the stimulation of TNF-α, caspase-8 specifically cleaves GSDMC to generate N-GSDMC, forming holes in cell membrane to induce pyroptosis (61). This evidence concerns the gene TNF and breast cancer.