AIM2 and acute respiratory distress syndrome: In LPS-induced ALI/ARDS, researchers found that NETs directly promoted alveolar macrophage pyroptosis through NET DNA-mediated activation of the AIM2 inflammasome, suggesting that NETs and the AIM2 sensor may be crucial therapeutic targets for the regulation of alveolar macrophage inflammasome-mediated immunopathology in ARDS (93).