No heterogeneity was observed in two studies assessing the pooled OR of ILD occurrence (pooled OR, I2 = 0%, p=0.606), so the IV method and a fixed-effect model were utilized for the analysis; the results demonstrated that serum SP-D was a potential risk factor for ILD occurrence (OR=4.66, 95%CI= 2.46, 8.86, p<0.001) (Figure 3). The gene discussed is SFTPD; the disease is interstitial lung disease.