Furthermore, the envelope glycoprotein Gn of the severe fever with thrombocytopenia syndrome virus (SFTSV) interacts with STING to impede STING dimerization and K27 ubiquitination, thereby hindering the assembly of the STING-TBK1 complex and subsequent signaling, which obstructs the nuclear translocation of IRF3 and p65, ultimately attenuating downstream innate immune signaling (55). This evidence concerns the gene STING1 and Fever.