Similarly, miR-582-3p in exosomes derived from hypoxic NSCLC cell lines (A549 and H1299) enhances proliferation, metastasis, and invasion of normoxic NSCLC cell lines by inhibiting the expression of secreted frizzled-related protein 1 (SFRP1), thus contributing to tumorigenesis through the modulation of various signaling pathways (127). Here, FRZB is linked to non-small cell lung carcinoma.