Additionally, miR-25-3p secreted by CRC cells targets KLF2 and KLF4 in vascular endothelial cells, downregulating the expression of vascular endothelial growth factor receptor 2 (VEGFR2), ZO-1, occludin, and Claudin5, thereby affecting neovascularization and PMN formation, promoting CRC metastasis (36). The gene discussed is KLF4; the disease is colorectal carcinoma.