CXCL12 and renal fibrosis: More than this, renal fibrosis is caused by the aggregation and activation of fibroblasts regulated by IL-17A, as well as a significant increase in the production of fibrocyte-related chemokine CXCL12 and activating factors Semaphorin7A and PDGF-BB, which significantly induce and participate in the pathogenesis of renal fibrosis [37].