IGC network (Fig. 2) shows four multiple interaction genes in cancer signaling and progression process; RHOA encodes for a protein of the Rho-GTPase family and is associated with signaling (Nam, Kim & Lee, 2019), Ras homologous A (RHOA) as a significant signaling hub in GC regulates several cellular processes, including the cytoskeletal structure and cell adhesion. This evidence concerns the gene RHOA and cancer.