Thus, inactivation of Hippo signaling and downstream activation of Yes-associated protein 1 (YAP) and WW-domain-containing transcription regulator 1 (TAZ) is common in a variety of malignancies such as breast, gastric, renal, hepatic, and hematologic cancers (Xu et al., 2019; Kyriazoglou et al., 2021; Ma et al., 2021; Noorbakhsh et al., 2021; Song et al., 2022; Wu et al., 2022; Liu et al., 2023a; Messina et al., 2023; Li et al., 2024; Yang et al., 2024). This evidence concerns the gene WWTR1 and hematopoietic and lymphoid cell neoplasm.