PTEN and breast carcinoma: Both PTEN and FBW7 inhibition in cancer are associated with resistance to γ-secretase inhibitors (GSI) which are used to treat breast cancer and are known to downregulate Notch (Palomero et al., 2007; Thompson et al., 2007; Baker et al., 2018; Fan et al., 2022; Chen et al., 2023).