Intriguingly, COL7A1 was found to be significantly over-expressed in lung squamous cell carcinoma (LUSC), where the interaction between laminin 332 and COL7A1 might lead to the activation of the PI3K signaling pathway, ultimately contributing to squamous cell carcinoma (Song et al., 2022). The gene discussed is COL7A1; the disease is squamous cell lung carcinoma.