PBRM1 and nonpapillary renal cell carcinoma: Furthermore, after the silencing of all these 5 prevalent mutations in ccRCC-related genes (VHL, PBRM1, BAP1, SETD2, and KDM5C) from primary tumors in metastatic ccRCC patients who underwent palliative nephrectomy, various associations between mutation status and survival rates were observed.