Furthermore, after the silencing of all these 5 prevalent mutations in ccRCC-related genes (VHL, PBRM1, BAP1, SETD2, and KDM5C) from primary tumors in metastatic ccRCC patients who underwent palliative nephrectomy, various associations between mutation status and survival rates were observed. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.