As a result, the high-risk group showed increased immune cell infiltration levels, such as activated CD4 memory T cells, CD8 T cells, Tregs, follicular helper T cells, and M0 macrophages, particularly Tregs, suggesting a state of functional impairment in tumor-infiltrating T cells (Díaz-Montero et al., 2020). The gene discussed is CD8A; the disease is neoplasm.