There is a high expression of LSD1 in osteosarcoma; histone methyltransferase SUV39H2 stabilizes LSD1, and then LSD1 regulates the methylation of CDH1 (cadherin 1, encoding E-cadherin) to repress the expression; transcription inhibition of CDH1 leads to the migration of osteosarcoma cells, thereby monitoring the progression of osteosarcoma.81 This evidence concerns the gene PRDM9 and osteosarcoma.