KDM1A and breast cancer: Meanwhile, phosphorylation of amino acid 112 controls the recruitment of LSD1 and p65 to promoters of target genes.19, 20, 21 Another study has shown that phosphorylated LSD1 can bind to the E-cadherin promoter region and regulate demethylation of methylated H3K4 to promote epithelial–mesenchymal transition; phosphorylation of LSD1 at ser112 is associated with the function of LSD1 in promoting breast cancer metastasis in vivo.22