KDM1A and central nervous system cancer: In glioma, a lack of methionine inhibits the growth of cancer cells and enhances the binding of LSD1 to E3 ubiquitin ligase CBL (casitas B-lineage lymphoma), and increased ubiquitination of LSD1 enhances expression of CXCL8 (CXC motif chemokine ligand 8) and methylated histone H3, which in turn affects the metabolism of the glycerophospholipid.41