KDM1A and liver cancer: Another study shows KAT8 also acetylates LSD1 at lysine K117, thus affecting the cytoplasmic localization and protein stability of LSD1 in liver cancer cells, thereby regulating the downstream FKBP8 (FKBP prolyl 0isomerase)-BCL2 (B-cell lymphoma-2) axis to promote tolerance of cellular to the drug and cell growth (Fig. 2).33