In glioma, a lack of methionine inhibits the growth of cancer cells and enhances the binding of LSD1 to E3 ubiquitin ligase CBL (casitas B-lineage lymphoma), and increased ubiquitination of LSD1 enhances expression of CXCL8 (CXC motif chemokine ligand 8) and methylated histone H3, which in turn affects the metabolism of the glycerophospholipid.41 The gene discussed is KDM1A; the disease is glioma.