Phosphorylation of EZH2 at serine 21 was found to be highly expressed in stem-like cells of glioblastoma multiforme, and this phosphorylation by protein kinase B (AKT) signaling facilitates STAT3 methylation by EZH2, thus enhancing STAT3 activity.9 The gene discussed is EZH2; the disease is glioblastoma.