In small-cell lung cancer, EZH2-mediated H3K27me3 silences the expression of schlafen family member 11, a factor implicated in DNA-damage repair deficiency, leading to chemoresistance, and suppression of EZH2 can reverse the resistance of primary epidermal growth factor receptor wild-type lung cancer cells to gefitinib.86 The gene discussed is EZH2; the disease is small cell lung carcinoma.