In pancreatic ductal adenocarcinoma, EZH2 silences GATA binding protein 6 (GATA6), an epithelial differentiation-related protein, through epigenetic modification, and participates in the transformation of pancreatic ductal adenocarcinoma to a subtype prone to metastasis.73 Here, GATA6 is linked to pancreatic ductal adenocarcinoma.