MTOR and neoplasm: ,106 In glioblastoma, lncRNA MDHDH promotes the degradation of MDH2 by mediating its binding to the proteasome subunit PSMA1 after generation, thereby reducing the NAD+/NADH ratio of cells, affecting energy supply and inducing autophagy through the AMPK/mTOR pathway, thus exerting tumor-inhibitory effects.107