As an adjacent sense transcript of SLC7A11, lncRNA SLC7A11-AS1 in colorectal cancer may contribute to the removal of excess ROS through up-regulation of the NRF2/SLC7A11 antioxidant system,160 and SLC7A11-AS1 has previously been found to reduce ROS levels by stabilizing NRF2 in pancreatic cancer.161. This evidence concerns the gene SLC7A11 and pancreatic neoplasm.