As a key regulator of autophagy, therapeutic strategies targeting PI3K/AKT/mTOR play an important role in enhancing tumor chemosensitivity and avoiding drug resistance and are expected to be used in the treatment of pancreatic cancer, lung cancer, and hepatocellular carcinoma.85, 86, 87, 88, 89 In addition, miR-145 protects follicular somatic granulosa cells from oxidative stress-induced apoptosis by targeting KLF4 in the H2O2-induced in vitro model and 3-NP-induced in vivo ovarian oxidative stress model to maintain normal ovarian function.90 The gene discussed is MTOR; the disease is hepatocellular carcinoma.