Not coincidentally, exosome-derived circTRPS1 from bladder cancer-derived cells can regulate intracellular ROS homeostasis and CD8+ T-cell depletion via the miR-141-3p/GLS1 axis, with GLS1-mediated glutamine metabolism involved in circTRPS1-mediated alterations.213. The gene discussed is GLS; the disease is urinary bladder cancer.