AKT1 and familial pancreatic carcinoma: By leveraging the established role of HIF1A-AS1 (the inherent antisense RNA counterpart of HIF-1α mRNA) in modulating HIF-1α′s oxidative response under conditions of oxidative stress within human induced pluripotent stem cell-derived endothelial cells,204 Fengyu Xu et al have discovered that HIF-1α can interact with the hypoxia-response elements of HIF1A-AS1 promoter, subsequently amplifying glycolysis and facilitating the resilience of pancreatic cancer towards gemcitabine through the AKT/YB1/HIF-1α cascade.205