In addition, studies have also found that melittin is an anti-tumor Chinese medicine with few side effects, which can inhibit the activity of Wnt/β-catenin signaling pathway, up-regulate the ratio of Bax/Bcl-2 in osteosarcoma cells and inhibit the expression of proliferative protein, thus inducing apoptosis and inhibiting proliferation of tumor cells (59). This evidence concerns the gene BCL2 and neoplasm.