Male gender (OR: 0.511, 95%CI: 0.314–0.830, p = 0.007), TC (OR: 0.544, 95% CI: 0.417–0.709, p < 0.001), TG (OR: 0.760, 95% CI: 0.582–0.992, p = 0.044), LDL-C (OR: 0.460, 95% CI: 0.331–0.640, p < 0.001), Apo B (OR: 0.081, 95% CI: 0.026–0.251, p < 0.001) were significantly associated with a low risk of AF. This evidence concerns the gene APOB and atrial fibrillation.