Aluminum chloride intoxication in Group II increased lipid peroxidation and decreased antioxidant parameters and affected interleukin-6 (IL-6), the tumor necrosis factor-alpha (TNF-α), acetylcholinesterase (AChE), and amyloid beta (Aβ), which lead to the induction of AD through injuring brain cells of AD rats. This evidence concerns the gene TNF and Alzheimer disease.