The cognitive impairments associated with AD have a variety of strong etiologies that include the characteristics of Aβ plaques and neurofibrillary tangles, excessive reactive oxygen species (ROS) generation, and inflammatory cytokine molecules production, such as tumor necrosis factor (TNF-α) and interleukin (IL)-6 that has a broad range of pharmacological properties, including neuroprotective, antimicrobial, antidiabetic, antioxidant, and anti-inflammatory [26]. Here, TNF is linked to Cognitive impairment.