As expected, the lean and obese groups exhibited significant baseline differences in body weight (BW), % body fat, fat mass, lean mass, bone mass, bone mineral density (BMD), fasting blood insulin (FBI), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), hemoglobin A1c (HbA1c), total cholesterol (CHOL), HDL, and LDL. The gene discussed is INS; the disease is Insulin resistance.