INS and obesity due to melanocortin 4 receptor deficiency: To ascertain the effects of preexisting obesity and reduced insulin sensitivity on the acute and long-term responses to SARS-Cov-2 delta infection (B.1.617.2 strain), we infected 10 lean and 10 obese, insulin-resistant rhesus macaques and followed multiple viral, immune, and metabolic parameters for an additional 6 months as depicted in Figure 1.